New opportunities of immunocorrection in complex treatment of cervical cancer patients

Etiologic role of human papilloma virus in cervical carcinoma is well known so this might be the base application interferonogenicimmunomodulators their complex treatment. Evaluation and place immunotherapy immunocorrection combination treatment one urgent problems both clinical immunology oncology. In study we used them – allokin-alpha (alloferon) together with plasmapheresis which contributes to detoxication enhancement tumor cells` sensitivity cytostatics locally advanced cancer patients receiving neoadjuvantpolychemotherapy (NCT). Clinical effect such was described our previous studies. The purpose present research immunomodulatorallokin-alpha (A) (PP) on cell-mediated immunity cytokines` composition serum. Cervical locally-advanced tumors were divided into two groups. control received NCT, basic consisted subgroups 1st course NCT additionally procedures gravitational PP, 2nd PP 6 injections allokin-alpha. Immunological parameters tested dynamics by flow cytometry ELISA. Dynamics revealed decrease CD19+ cells all groups, Treg group; lymphocytes, CD3+ CD8+ after + PP; activated CD3+HLA-DR+ A though amount CD8+HLA-DR+ elevated. When applied levels found lower than additional administration A. Analysis showed increase IL-8 but caused its` decrease. IL-10 level minimal having Application prevented elevation inflammatory (IL-1β TNFα) observed group neoadjuvant Such a cytokines suggests that chemotherapy useful tumors.